Division of Biology and Medicine
Molecular Microbiology & Immunology
![](/sites/default/files/styles/portrait_classic_xsml/public/2021-05/slee404_photo_.jpg?h=c6315961&itok=GPoyUDv-)
Sanghyun Lee
Assistant Professor of Molecular Microbiology and Immunology
Biography
The main focus of my laboratory is understanding dynamic host-virus interaction in cells and animals, such as how the host controls viral infection and how viruses counteract against the host immune system. We utilize a mouse model with a variety of knock-out and knock-in mouse lines to investigate viral pathogenesis, and also employ unbiased screening using CRISPR knock-out (CRISPRko) and CRISPR activation (CRISPRa) techniques to discover novel anti-viral or pro-viral cellular genes.